Brian Ceresa Lab
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About
The Ceresa Lab studies the molecular mechanisms that regulate epidermal growth factor receptor (EGFR) signaling with the goal of enhancing corneal re-epithelialization. Our lab combines biochemical, cell biological and whole animal studies to understand fundamental molecular mechanisms that regulate EGFR activity. Ultimately, we want to develop compounds that promote corneal epithelial homeostasis to minimize patient distress, the likelihood of ocular infections and the potential for blindness.
Key Research Areas
- Drug discovery
- Corneal epithelial homeostasis
- Wound healing
- Receptor pharmacology
- Membrane trafficking
- Signal Transduction
- E3 ubiquitin ligases/ubiquitination
Current Projects
- Chemical Optimization of CBL antagonists to enhance Corneal re-epithelialization
- EGFR signaling in the diabetic cornea epithelium
Team
- Brian Ceresa - Director
- Lisandra Plana – Research Assistant III
- Leighton Avera – Graduate Student (Pharmacology and Toxicology)
- Andrew Le – UofL undergraduate Biology major
Recent Publications
- Gosney, J.A.*, Wilkey, D.W., Merchant, M.L., Ceresa, B.P.,(2018) Proteomics reveals novel Protein associations with early endosomes in an Epidermal Growth Factor-dependent manner. J Biol Chem. 293(16):5895-5908. PMCID:PMC5912451.
- Rush, J.S., Peterson, J.L, Ceresa, B.P., (2018) Betacellulin (BTC) Biases the EGFR to Dimerize with ErbB3. MolPharmacol. 94:1382-1390. PMCID:PMC6207915.
- Kim, C., States, J.C., Ceresa, B.P., (2020) Chronic and acute arsenic exposure enhance EGFR expression via distinct molecular mechanisms. Toxicol In Vitro 67:104925 PMCID: PMC7375208
- Crotchett, B.L.M. and Ceresa, B.P. (2021) Knockout of c-Cbl Slows EGFR Endocytic Trafficking and Enhances EGFR Signaling Despite Incompletely Blocking Receptor Ubiquitylation, Pharm. Res. & Persp., 9(2):e00756. PMCID: PMC8019067
- Kim, C., Chen, J., Ceresa, B.P. (2021) Chronic Arsenic Increases Cell Migration in BEAS-2B Cells by Increasing Cell Speed, Cell Persistence, and Cell Protrusion Length, Experimental Cell Research 408(1):112852 PMCID:PMC8530977
- Ceresa, B.P. (2021) Prime Time for the Recycling Endosome EMBO J, 40(14):e108758. PMID: 34159621
- Tarvestad-Laise, K.E., and Ceresa, B.P., Modulating Growth Factor Receptor Signaling to Promote Corneal Epithelial Homeostasis, Cells, doi: 10.3390/cells12232730 PMCID: PMC10706396
- Tarvestad-Laise, K.E., and Ceresa, B.P. (2023) c-Met signaling is negatively regulated by c-Cbl/Cbl-b in human corneal epithelial cells. J. of Biol Chem 299(10):105233 PMCID:PMC10622846\