Hwangbo Lab
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About
Using Drosophila melanogaster (the fruit fly) as a model organism, our lab aims to understand: 1) how behavioral and cellular homeostasis decline during the aging process; 2) how environmental factors such as diet, temperature and light impact behavioral and cellular aging and modulate the organismal aging process; and 3) how to discover genetic and pharmacological interventions for delaying aging and promoting health. Specific topics include sleep and circadian rhythms, feeding behaviors, lifespan extension through dietary restriction, progeria syndrome, proteostasis (protein homeostasis) and neurodegeneration. We actively recruit motivated and talented graduate and undergraduate students who are genuinely interested in these topics.
Team
Dae-Sung Hwangbo, Assistant Professor
ds.hwangbo@louisville.edu
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- Mubaraq Opoola, PhD candidate, mubaraq.opoola@louisville.edu
- Bre Beard, PhD candidate, breanna.beard@louisville.edu
- Pallavi Padmaraj, PhD student, pallavi.p.1@louisville.edu
- Aubrey Reitzel, Undergraduate Researcher, aubrey.reitzel@louisville.edu
- Bailey Ramirez, Undergraduate Researcher, bailey.ramirez@louisville.edu
- Krish Patel, Undergraduate Researcher, krish.patel@louisville.edu
- Dunklin Rangitsch, Undergraduate Researcher, matthew.rangitsch@louisville.edu
- Esha Patel, Undergraduate Researcher, esha.patel@louisville.edu
- John Huynh, Undergraduate Researcher, john.huynh@louisville.edu
- Ranga Chennakesavula, Undergraduate Researcher, ranga.chennakesavula@louisville.edu
Our Work
- Aging
- Dietary Restriction
- Feeding Behavior
- Sleep
- Circadian Rhythms
- Metabolism
- Drosophila
- Molecular Genetics
- Behavioral Neuroscience
- Human Disease Models
- Mechanisms of Lifespan Extension and Health Promotion by Dietary Restriction in Drosophila
- Genetic Mechanisms of Circadian Clock-Mediated Dietary Restriction in Drosophila.
- Understanding the Behavioral, Genetic, and Neuronal Basis of the Sleep-Feeding Conflict in Drosophila.
- Mechanisms of Sugar-Mediated Overfeeding and Obesity in Drosophila
- Roles of Fat Body Circadian Clock in Sleep, Feeding Behavior, and Lifespan
- Beard, B., Bohn A., Opoola, M., Hwangbo, DS. Con-DAM: Simultaneous measurement of food intake and sleep in Drosophila at a single fly resolution. microPublication Biology. https://pubmed.ncbi.nlm.nih.gov/39005561/
- Xu B, Hwangbo DS, Saurabh S, Rosensweig C, Allada R, et al. (2024) Temperature-driven coordination of circadian transcriptional regulation. PLOS Computational Biology 20(4): e1012029. https://pubmed.ncbi.nlm.nih.gov/38648221/
- Sember E, Chennakesavula R, Beard B, Opoola M, Hwangbo DS (2024). Dietary Restriction Fails to Extend Lifespan of Drosophila Model of Werner Syndrome. G3 (Bethesda) Genes|Genomes|Genetics. https://pubmed.ncbi.nlm.nih.gov/38491858/
- Opoola, M; Fitzgerald, L; Hwangbo, DS (2024). Con-FLIC: concurrent measurement of feeding behaviors and food consumption in Drosophila at single-fly resolution. microPublication Biology. https://pubmed.ncbi.nlm.nih.gov/38487478/
- Hwangbo, D.-S., Kwon, Y.-J., Iwanaszko, M., Jiang, P., Abbasi, L., Wright, N., Alli, S., Hutchison, A.L., Dinner, A.R., Braun, R.I., Allada, R. (2023). Dietary Restriction Impacts Peripheral Circadian Clock Output Important for Longevity in Drosophila. eLife 12:RP86191. https://doi.org/10.7554/eLife.86191.1
- Yildirim E*, Curtis R, Hwangbo DS* (2021). Roles of peripheral clocks: lessons from the fly. FEBS Lett. 2021; 00: 1– 31. (*co-corresponding author). https://pubmed.ncbi.nlm.nih.gov/34862983/
- Hwangbo DS*#, Lee HY*, Abozaid LS, and Min KJ#. (2020). Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms. Nutrients.12(4):1194. (*equal contribution, # co-corresponding author). https://pubmed.ncbi.nlm.nih.gov/32344591/