Dr. Running Lab
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About
My lab uses a molecular, genetic, cellular and biochemical techniques to address questions about how plants develop from a single cell to an adult plant with many specialized cell types. These include how multicellularity and differentiation processes were first established in plants, how plant stem cells function, and how to harness this knowledge for practical applications like producing biofuels and increasing agricultural yield.
Key Research Areas
- Genetics
- Developmental Biology
- Cell Biology
- Biochemistry
- Plant Biology
- Plant Stem Cells
- Biofuels
- Biotechnology
- Use-inspired research
- Bioinspired design
Team
Dr. Mark Running, Professor
mark.running@louisville.edu | View Research Profile
- Dr. Jesse Rozsa, Visiting Professor
- Esiosa Adewale, Graduate Student
- Matthew Hart, Graduate Student
- Chelsea Pipkin, Graduate Student
Our Work
- Establishment of multicellularity in plants
- Lipid post-translational modifications in plant development
- The role of prenylation in regulation of protein function
- The role of prenylation in establishment of plant cell polarity
- Designing bioinspired antimicrobial surfaces for medical applications
- Qu, C, Rozsa, J., Running, M., McNamara, S., Walsh, K. (2024). I-GLAD: a new strategy for fabricating antibacterial surfaces. Discover Nano 19, 17. https://doi.org/10.1186/s11671-024-03959-0
- Bao, L., Running, M. P. (2023) 3-D Time-Lapse Imaging of Cell Wall Dynamics Using Calcofluor in the Moss Physcomitrium patens. J. Vis. Exp. 192, e64651, doi:10.3791/64651.
- Qu, C., Rozsa, J.L., Jung, H.-J., Williams, A.R., Markin, E.K., Running, M.P., McNamara, S., and Walsh, K.M. (2023). Bio-inspired antimicrobial surfaces fabricated by glancing angle deposition. Scientific Reports 13(1), 207. doi: 10.1038/s41598-022-27225-4.
- Bao, L., Ren, J., Nguyen, M., Slusarczyk, A.S., Thole, J.M., Martinez, S.P., Huang, J., Fujita, T., and Running, M.P. (2022). The Cellular Function of ROP GTPase prenylation is important for multicelluarity in the moss Physcomitrium patens. Development 149(12), dev200279. doi:10.1242/dev.200279.
- Paxton, W.F., Rozsa, J.L., Brooks, M.M., Running, M.P., Schultz, D.J., Jasinski, J.B., Jung, H.J., and Akram, M.Z., (2021). A Scalable Approach to Topographically Mediated Antimicrobial Surfaces Based on Diamond. Journal of Nanobiotechnology 19, 458. https://doi.org/10.1186/s12951-021-01218-3
- Cawthon, S.M., Rozsa, J.L., and Running, M.P. (2021). The Sterilization of Escherichia coli with Black Diamond-Coated Silicon. The Cardinal Edge 1(1), 10. DOI: 10.18297/tce/vol1/iss1/10
- White, A.J., Perez-Martinez, S., and Running, M.P. (2021). The Effects of PPAL-1 in Arabidopsis Gamete Development. The Cardinal Edge 1(1),11. DOI: 10.18297/tce/vol1/iss1/11
- Wang, S., Guan, Y., Wang, Q., Zhao, J. Sung, G., Hu, X., Running., M.P., Sung, H., and Huang., J. (2020). A mycorrhizae-like gene regulates stem cell and gametophore development in mosses. Nature Communications 11, 2030. DOI: 10.1038/s41467-020-15967-6.