Hein Lab
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About
Dr. Hein’s research program incorporates precision environmental health and precision medicine. This includes research in personalized medicine and individual susceptibility to environmental diseases. Research in molecular epidemiology identifies individuals genetically susceptible to the development of cancer and other diseases from environmental and occupational chemicals to focus treatment and prevention public health strategies on those at greatest risk. Research in pharmacogenetics/genomics and personalized/precision medicine improves our understanding of the genetic causes for drug failure and/or drug toxicity to optimize clinical drug therapy for each individual patient. Research in functional genomics improves understanding of the mechanistic and clinical consequences of genetic variation in the biotransformation of environmental chemicals, carcinogens, and drugs. The research program has been funded continuously since 1983 by grants and contracts from the National Institutes of Health and other federal and private foundations and industry. He has coauthored over 275 peer-reviewed journal articles and book chapters, 75 gene sequences, and over 700 abstracts (Google Scholar 18,000 citations (h-index=67) in the scientific literature.
Key Research Areas
- Precision environmental health sciences
- Precision medicine
- Chemical carcinogenesis
- Chemical risk assessment
- Pharmacogenomics
- N-acetyltransferases
- Molecular epidemiology
- Environmental chemicals
Current Projects
- Genotoxicity of azo dyes present in food and clothing
- Genotoxicity of nitroarenes present in air pollution emissions from fossil fuels
Team
- Mariam R. Habil, MBChB, M.S., Ph.D., postdoctoral fellow; mariam.refaatzakyhabil@louisville.edu
- Co-mentor for MD/PhD student
- Distinction in research medical student
- Undergraduate students
Recent Publications
- Pharmacogenomic-guided selection of the optimal drug and dosage regimen
- Metabolic effects of heterocyclic amines on insulin‑induced AKT phosphorylation and gluconeogenic gene expression are modified by N-acetyltransferase 2 genetic polymorphism
- Metabolism and genotoxicity of 4,4’-oxydianiline is dependent on N-acetyltransferase 2 genetic polymorphism
- PharmVar NAT2 Gene Expert Panel: NAT2 Allele Nomenclature Update and Transition to PharmVar
- Bioactivation, Mutagenicity, DNA Damage, and Oxidative Stress Induced by 3,4-Dimethylaniline
- Investigation on regulation of N-acetyltransferase 2 expression by nuclear receptors in human hepatocytes
Heterocyclic Amines Disrupt Lipid Homeostasis in Cryopreserved Human Hepatocytes
Funding
- Louisville Clinical and Translational Research Center (LCTRC)
- Research Experiences and Training Coordination Core
- University of Louisville Center for Integrative Environmental Health Sciences
- FII Workshop 2020
- Environmental Exposure and Cardiometabolic Disease
- Superfund Training Core
The interaction between NAT2 acetylator status and exposure to tobacco smoke on ovarian reserve and in vitro fertilization outcomes