Sandra Diven Laboratory
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About
The Diven Lab research interests include how environmental chemicals, such as hexavalent chromium, and other metals, can transform normal cells into cancer cells. These studies have focused on DNA repair deficiency and its impact on chromosome instability as a driving mechanism to cellular transformation and the development of disease. Currently, she is pursuing how cells exposed to these chemicals induce DNA and chromosomal damage yet are able to survive and evade the normal cell death pathways that should occur in order to protect the organism from disease
Key Research Areas
- Metal-induced cancer
- Inhibition of DNA repair by metals
- How metals disrupt chromosome maintenance and stability
- How metals impact stem cells
Current Projects
- Metal-Induced Chromosome Instability in Lung Cancer
- Metal-Induced Impacts on DNA Repair
- Metal-Induced Genomic Instability
- Metal-Induced Reprogramming of Stem Cells