Luzzio Laboratory
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About
The long term goals of our research are focused at the interface of chemistry and biology. We are interested in solving problems in biomedicine using the techniques and application of synthetic organic, medicinal and natural products chemistry. Toward our goals in biomedicine we concentrate our efforts in the following three areas of organic chemistry: (1) the development of new methods and strategy which are applicable to the synthesis of biologically active compounds; (2) the total synthesis of a wide range of complex molecules including natural products, pharmaceutical leads and their analogues; and (3) the isolation and discovery of biologically active compounds from natural sources.
- Total Synthesis
- Synthetic Methods
- Medicial Chemistry
- Natural Products
Recent Publications
- Diversity of Heterocyclic Reactants in the Click Reaction
F. A. Luzzio in Advances in Heterocyclic Chemistry Volume 143, 2024. - Iron-Catalyzed Oxidation of Phthalimide-Derived Hydroxylactams and Isoindolinones
B. L. Adjei and F. A. Luzzio* Tetrahedron2023, 149, 133739. - Synthesis of C4’ Uridyl Aryloxazoles: A “Heterohomologative Approach”
P. J. Monsen and F. A. Luzzio* Heterocycles2023, 106, 1334-1354. - An Oxidation Study of Phthalimide-Derived Hydroxylactams
B. L. Adjei and F. A. Luzzio* Molecules2022, 27, 548-557. - 1,4-Oxa/Thia-2-Azoles
F. A. Luzzio in Comprehensive Heterocyclic Chemistry (Elsevier) 2022 Volume 6, pp 96-119. - Chemoenzymatic Route to Stereodefined 2-(Azidophenyl)oxazolines for Click Chemistry
P. J. Monsen and F. A. Luzzio* Tetrahedron Lett. 2021, 63, 152717 - Applicability of Aluminum Amalgam to the Reduction of Arylnitro Groups
P. J. Monsen and F. A. Luzzio* Tetrahedron Lett. 2020, 61, 152575. - Synthesis and Reactivity of Fluorinated Heterocycles
F. A Luzzio in Advances in Heterocyclic Chemistry. Vol. 131; Scriven, E. F. V. & Ramsden, C. A. (Eds.), Elsevier: 2020, p. 1-84.
Team
Frederick A. Luzzio, Principal Investigator
faluzz01@louisville.edu | View Research Profile
- Bernard L. Adjei, Doctoral Student
- Shramana Ghosh, Doctoral Student
- Ashleigh Lucas, Doctoral Student