The Joseph Moore Laboratory of Cardiac Extracellular Matrix
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About
Our laboratory focuses on understanding the fundamental biology of the cardiac extracellular matrix (ECM) and its complex role in cardiovascular health and disease. The cardiac ECM not only supports the heart’s three-dimensional structure and organizes its diverse cellular components but also serves as a pivotal signaling hub, enabling dynamic communication between the cardiac stroma and parenchyma. Despite its critical role, our knowledge of this communication and its importance in cardiac development and disease processes remains limited. This gap highlights the laboratory’s main goals: uncovering new ECM-mediated biological processes, mapping the signaling networks involved in cardiac development, stress responses, and heart failure, and studying how ECM structural changes impact cardiac function. Ultimately, the lab aims to identify ECM-centered processes that could be targeted for therapeutic intervention in heart failure, with the potential to reshape treatment approaches and improve patient outcomes.
Key Research Areas
Unraveling the Role of Extracellular Matrix in Cardiovascular Cell Communication and Heart Health
Transforming Cardiac Structure and Function Through ECM Composition and Architecture
Targeting ECM Dynamics for Cardiac Repair and Regeneration
Recent Publications
Fischer AG, Elliott EM, Brittian KR, Garrett L, Sadri G, Aebersold J, Singhal RA, Nong Y, Leask A, Jones SP, Moore IV JB. Matricellular protein CCN1 promotes collagen alignment and scar integrity after myocardial infarction. Matrix Biol. 2024 Nov; 133:14-32.
Sadri G, Fischer AG, Brittian KR, Elliott E, Nystoriak MA, Uchida S, Wysoczynski M, Leask A, Jones SP, and Moore IV JB. Collagen Type XIX Regulates Cardiac Extracellular Matrix Structure and Ventricular Function. Matrix Biology. 2022 Mar 25; 109:49-69.
Sansbury BE, Nystoriak MA, Uchida S, Wysoczynski M, and Moore IV JB. Rigor Me This: What Are the Basic Criteria for a Rigorous, Transparent, and Reproducible Scientific Study? Frontiers in Cardiovascular Medicine. 2022 July 1; 9: 914612.
Hosen RM, Goody PR, Zietzer A, Xiang X, Niepmann ST, Sedaghat A, Tiyerili V, Chennupati R, Moore IV JB, Boon RA, Uchida S, Sinning J, Zimmer S, Latz E, Werner N, Nickenig G, and Jansen F. Circulating MicroRNA-122-5p Is Associated with a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles. Circulation. 2022 Dec 13; 146(24):1836-1854
Moore IV JB and Wysoczynski M. Immunomodulatory Effects of Cell Therapy After Myocardial Infarction. Journal of Cellular Immunology. 2021 May 5; 3(2): 85–90
Ohanyan V, Raph SM, Dwenger MM, Hu X, Pucci T, Mack G, Moore IV JB, Chilian WM, Bhatnagar A, and Nystoriak MA. Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins. Circulation Research. 2021 Jan 27.
Heidel JS, Fischer AG, Tang XL, Sadri G, Wu WJ, Moisa CR, Stowers H, Sandella N, Wysoczynski M, Uchida S, and Moore IV JB. The Effect of Cardiogenic Factors on Cardiac Mesenchymal Cell Anti-Fibrogenic Paracrine Signaling and Therapeutic Performance. Theranostics. 2020 Jan 1;10(4):1514-1530.
Moore IV JB, Sadri G, Fischer AG, Weirick T, Militello G, Wysoczynski M, Gumpert AM, Braun T, and Uchida S. The A-to-I RNA Editing Enzyme Adar1 is Essential for Normal Embryonic Cardiac Growth and Development. Circ Res. 2020 Jul 31;127(4):550-552.