Hardesty Lab
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About
The Hardesty laboratory is focused on identifying mechanisms of compromised liver regeneration and treatment options that restore liver regeneration and liver function in alcohol-associated liver disease (ALD) and metabolic dysfunction associated steatotic liver disease (MASLD). Liver diseases are thought to persist due to chronic inflammation that goes unresolved preventing liver regeneration. This is a common feature in multiple end-stage liver diseases for which there are no adequate treatments or therapies.
Key Research Areas
- Mechanisms of compromised liver regeneration in ALD and MASLD and the identification of therapies.
- Mechanisms of impaired liver function in ALD and MASLD and the identification of therapies.
- Identify markers and mechanisms of corticosteroid non-responsiveness in alcohol-associated hepatitis.
- Develop and utilize Visium Spatial Transcriptomic approaches to study liver pathology to identify novel cell types and transcriptomic signatures.
- Use a health-centric approach to identify novel therapeutics targets for MASLD.
- Investigate mitochondrial aberrations in end stage liver diseases.
Recent Publications
- Gripshover TC, Treves RS, Hardesty JE. Identification of Preclinical Biomarkers of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) versus MASLD and Increased Alcohol Intake and the Impact of Diet. Am J Pathol. 2025 Jun 12;. doi: 10.1016/j.ajpath.2025.05.013. [Epub ahead of print] PubMed PMID: 40516914.
- Gripshover TC, Treves RS, Rouchka EC, Chariker JH, Zheng S, Hudson E, Smith ML, Singal AK, McClain CJ, Hardesty JE. Visium spatial transcriptomics and proteomics identifies novel hepatic cell populations and transcriptomic signatures of alcohol-associated hepatitis. Alcohol Clin Exp Res (Hoboken). 2025 Jan;49(1):106-116. doi: 10.1111/acer.15494. Epub 2024 Nov 26. PubMed PMID: 39592394; PubMed Central PMCID: PMC11747835.
- Treves, R. S., Gripshover, T. C., & Hardesty, J. E. (2025). STATom@ic: R Package for Automated Statistical Analysis of Omic Datasets. Stats, 8(1), 18. https://doi.org/10.3390/stats8010018
Team
- Dr. Tyler Gripshover, Ph.D., Postdoctoral Research Associate, Tyler.gripshover@louisville.edu
- Rui Treves, Data Analyst, Rui.treves@louisville.edu